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I believe in that especially for young investigators. Hershko: Well, it's not my nature, but in science I think that you should find unique problems, and you should find a niche, which is not in the mainstream. Is that your nature to go in a place where no one else is or was it something specific about this problem that caught your attention? Steve: When you were doing your work for which you were awarded the Nobel Prize, everybody was looking at the synthesis of proteins, and you went with very few other people in a different direction to look at the degradation of proteins. We spoke, as you'll easily be able to tell, in the restaurant next to the Inselhalle, the site of the Lindau meeting. He shared the Nobel for the discovery of the systems whereby cells break down proteins. Later in this episode, Scientific American Editor in Chief Mariette DiChristina talks about the Google Science Fair, but first up is Avram Hershko. And I had a chance to catch up to a few of the laureates between events-interviews I'll be rolling out over the next few weeks.

Twenty-three Nobel winners lectured and schmoozed with more than 550 graduate students or post doctoral fellows at the beginning of their scientific careers. If you have listened last week you know that I was recently in Lindau, Germany for the 61st annual Lindau Nobel laureate meeting, which this year featured laureates in Physiology or Medicine and in Chemistry. Steve: That's Avram Hershko, who won the Nobel Prize in Chemistry in 2004.

In the symphony you have, this side is a huge orchestra with thousands of players-they are the proteins. Hershko: So you turn on a machine by making a protein and then you have to turn it off, so I liken it to an orchestra. Steve: Welcome to the Scientific American podcast, Science Talk, posted on July 27th, 2011. And Scientific American Editor in Chief Mariette DiChristina discusses the recent inaugural Google Science Fair Nobel laureate Avram Hershko, who determined cellular mechanisms for breaking down proteins, talks about his research in a conversation recorded at the Lindau Nobel Laureate Meeting in Lindau, Germany.